Nyhetsbrev 03/2023 Newsletter |
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Pharmaceutical Sciences Laboratory, Åbo Akademi |
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Året 2023 har börjat med många evenemang, publikationer och nya medlemmar, och dessutom nya redaktörer! Allt går att läsa i årets första nyhetsbrev, och vi önskar att fortsättningen av året är lika händelsefullt! The year 2023 has started with many events, publications and new members, as well as new editors! You can read all about it in the year's first newsletter, and we wish that the rest of the year will be as eventful! Trevlig läsning! | Happy reading! |
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Innehåll | Table of Contents |
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Studentnytt Nyheter Kommande evenemang Hälsningar från möten Nya PSL-medlemmar Nya publikationer
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Student news News Upcoming events Greetings from meetings New PSL members New publications
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Studentnytt | Student news |
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Gäster från Sverige I början av januari gästades provisorskursen ”Klinisk farmaci och sjukhusfarmaci” av Ulrika Gillespie och Henrik Cam från Akademiska Sjukhuset i Uppsala. Svenskarna höll en uppskattad föreläsning om hur de har utvecklat den kliniska farmacin i Uppsala så att kliniska farmaceuter (=provisorer) har en aktiv roll i utformningen av patienters läkemedelsbehandling på sjukhuset. Ulrika och Henrik gav även en forskarpresentation samt drog en workshop på kursen. Guests from Sweden The course for Master's students in pharmacy "Klinisk farmaci och sjukhusfarmaci" was visited by Ulrika Gillespie and Henrik Cam from Uppsala University Hospital in the beginning of January. The Swedes held a much appreciated seminar on how they have developed clinical pharmacy in Uppsala so that clinical pharmacists have an active role in the design of the pharmaceutical treatment of patients at the hospital. Ulrika and Henrik even held a research presentation and a workshop at the course. |
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Ex Tempores årsfest Lördagen den 11.2. firades Ex Tempores 31. verksamhetsår med årsfest på Kuppis Paviljong. Årets årsfestmarskalker var Carolina Paqvalén och Natalie Wikström. Det var fullt hus och personalen representerades av professorerna Tappi och Jessica som även hade äran att leverera kvällens festtal, samt doktorand Sara Rosenberg som också representerade Provisorsförbundet (Proviisoriyhdistys ry). Eftersom både efterfesten och sillisen gick av stapeln på Ett Ställe Där Det Inte Får Fotograferas, så får ni hålla tillgodo med detta suddiga foto från Solennakten där Sara framför Provisorsförbundets hälsningar. |
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Ex Tempore annual celebration On Saturday 11th of February, our student association Ex Tempore celebrated its 31st year of operation with an annual party at the Kupittaa Pavilion. It was a full house and the staff was represented by professors Tappi and Jessica, who also had the honour of delivering this year’s celebration speech, and PhD candidate Sara Rosenberg, who also represented the Finland's Association of Pharmacists (Proviisoriyhdistys ry). Since both the after-party and Sunday ”brunch” party took place at a place where photos are not allowed, you will have to make do with this blurry photo from the Solemnity part of the evening where Sara delivers the Association of Pharmacists’ greetings. |
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Ex Tempore 31st annual party pictures are taken by @kameranton |
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Susanna Öhman, studerande på magisterprogrammet i Läkemedelsutveckling och Medicinsk Teknologi, valdes till Pharma Industry Future Stars (PIF stars) - nätverksprogrammet för universitetsstuderande. Programmet ger deltagarna information om jobb och karriärmöjligheter inom läkemedelsindustrin. Teman är bland annat läkemedelsutveckling och forskning, tillverkning och distribution, marknadsföring och försäljning, internationella aspekter samt läkemedelsindustrins verksamhetsmiljö och samhällsansvar. Susanna berättar att så här långt kan hon varmt rekommendera programmet! |
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Susanna Öhman, MSc student in Drug Development & Medical Technology, was selected to the Pharma Industry Future Stars (PIF Stars) networking programme for university-level students. The programme offers the participants information about the jobs and career potentials in the pharmaceutical industry. The themes include pharmaceutical development and research, manufacturing and distribution, marketing and sales, international aspects as well as the operating environment and societal responsibility of the pharmaceutical industry. Susanna says that so far, she can warmly recommend the programme! |
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PSL nyhetsbrevet har två nya redaktörer! Nyhetsbrevet har två nya redaktörer, doktoranderna Fanny Frejborg och Oliver Koivisto! Hoppas att ni välkomnar oss! The PSL newsletter has two new editors! The newsletter has two new editors, the PhD researchers Fanny Frejborg and Oliver Koivisto! We hope that you welcome us! |
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PSL fredagsseminarierna har börjat Fredagsseminarierna är i full gång igen! De sker varje fredag kl 15.00 i Aud Farmaci. Schemat hittar du här! Den 3.2. höll Johan Nyman en viktig seminarie om labbpraxis, materialet hittas här! |
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The PSL Friday seminars have begun The Friday seminars have started again! They take place every Friday at 15.00 in Aud Farmaci. The schedule can be found here. Johan Nyman held a very important seminar about laboratory practices the 3rd of February, the materials of which can be found here! |
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Dagsverke Den 25.1. stod vi som värd för Dagsverkeeleven Filip från Hoplaxskolan/Munksnäs som därmed fick bekanta sig med livet som forskare för en dag. Doktorand Meixin Ran fungerade som hans handledare för dagen, under vilken han bl.a. fick ta del av Hongbos forskningsgruppsmöte, studera celler i mikroskop och lära sig om förvaring av dessa i antingen -80℃ eller flytande kväve (−196 °C). Vi hoppas vi får se Filip här som studerande/forskare en dag! Filip, a student from Hoplaxskolan/Munksnäs primary school, performed his "Dagsverke" duty in Pharmaceutical Sciences Laboratory on January 25th . Like a graduate student, accompanied by PhD Meixin, he attended the group meeting of Hongbo Zhang and introduced himself, and was very excited to observe cell morphology with a microscope and learn about their storage in ultra-low temperature (-80℃ and liquid nitrogen). We hope to see Filip as a student/researcher with us one day! |
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Hälsningar från möten | Greetings from meetings |
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Medlemmar från PSL har redan haft möjligheten att delta i några möten, evenemang och konferenser detta år som just har börjat! Några möten är från förra årets december. Ni kan läsa mer om dem nedan. Members from PSL have already had the chance to attend some meetings, events and conferences this year that just begun! Some meetings are from last year's December. You can read more about them below. |
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Annual Christmas cruise, 20th of December, Turku The Annual Christmas cruise last December included staff and researchers from Biocity 2nd and 3rd floor, from the fields of pharmacy, biochemistry and cell biology! We enjoyed presentations where different the research groups were introduced, played some games and enjoyed networking and dining! |
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CompLifeSci Kick-off seminar, 7th of December, Turku Quite a few PSL members took part in the Kick-off meeting of the CompLifeSci research programme on the 7th of December 2022 on a Viking Line picnic cruise. CompLifeSci, or Computational and Molecular Methodologies for Life Sciences is one of the Biocity research programs for 2022-2026, and it links several research groups and around a hundred researchers working on these themes in Turku region. The program supports local networking and collaboration and is open to new members. The seminar program included exciting scientific presentations by guest speakers as well as the local groups and planning of CompLifeSci network activities. There was also ample time for networking with colleagues. In case you are interested in joining the CompLifeSci email list, please contact Tuomas Borman (complifesci-coordinator@utu.fi). From PSL, Outi Salo-Ahen’s and Anne Filppula’s groups are part of this particular research program. |
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5th Scandinavian Blood-Brain Barrier Network symposium, 19-20th of January, Kuopio A team of 7 people led by associate professor Hongbo Zhang participated in the 5th Scandinavian Blood-brain Barrier Network (SBBN) symposium at the University of Eastern Finland, Kuopio, on Thursday and Friday, 19-20.1.2023. During the meeting, the team provided six posters on behalf of the Pharmaceutical Sciences Laboratory, which can be read here. |
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12th Symposium on Pharmaceutical Profiling in Drug Discovery and Development, 18-20th of January, Uppsala, Sweden Four PhD researchers from PSL, Alaa Mahran, Jyoti Verma, Fadak Hawaili, and Rathna Mathiyalagan, attended the 12th Symposium on Pharmaceutical Profiling in Drug Discovery and Development held on 18-20 January at Uppsala University, Stockholm, Sweden. There were two workshops by Prof. Olivia Merkel, “Parenteral administration of RNA medicines,” and by Prof. Yvonne Perrie, “Microfluidic production of nanoparticles”. Furthermore, Alaa and Rathna participated in a poster presentation. A participant certificate was issued to the participants. "Overall, we had excellent time-sharing about research during the symposium days, and the topics they presented were fascinating and insightful." |
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PSL celebrates the Chinese New Year with dinner, 21st of January, Turku To celebrate the Chinese New Year, Associate Professor Hongbo Zhang had gracefully invited all of PSL for hot pot dinner at Brokadi Hansa. The atmosphere, food and company was great, and we thank Hongbo Zhang for inviting us! |
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Nya PSL-medlemmar | New PSL members |
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Vi har många nya medlemmar att välkomna i början av detta år! Nedan introducerar de sig själva och vi är glada att motta dem! We have many new members to welcome at the start of this year! Below they introduce themselves and we are glad to receive them! |
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Chetan Pathak. "I am Chetan Pathak (M.Pharm.), and I am a PhD student at Abo Akademi University's PSL. Prof. Jessica Rosenholm, Prof. Tapani Viitala, and Dr. Kuldeep Bansal will supervise my work. I have 12+ years of combined experience in the formulation and development, technology transfer, and project management departments (in pharmaceutical research and manufacturing organizations) for injectable dosage forms.
I decided to pursue a PhD in order to discover and establish a globally accepted solution for challenging formulations. I intend to work on poly (jasmine lactone)-based drug delivery systems to improve the solubility and stability of anticancer, immunosuppressive, and lyophilized formulations, among other things." |
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Xin Yang graduated from China Pharmaceutical University with a master's degree in pharmaceutical engineering. His master's research focused on nanocomposite hydrogel dressings for chronic wound healing. After completing his master's degree, he joined Hongbo's research group as a Ph.D. student. His PhD work focuses on the development of microfluidic synthesis technology for nano drug delivery systems. |
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Saule Nauryz received her bachelor's and master's degrees in electrochemistry, and she was engaged in developing lithium-ion batteries at Al-Farabi Kazakh National University in Almaty, Kazakhstan. Now Saule is a Ph.D. student at the Eurasian National University named after L.N. Gumilyov" in Astana, Kazakhstan. The topic of her scientific dissertation was "Investigation of the physicochemical properties of thermosensitive fluorinated copolymers based on poly-2-alkyl-oxazolines in mixed aqueous-organic solvents." At the invitation of Professor Hongbo Zhang and under the guidance of Professor Sergey Filippov, Saule is engaged in the study of fluorinated copolymers based on poly-2-alkyl-oxazolines in the Laboratory of Pharmaceutical Sciences of Abo Academy University. |
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Svetlana Kovtareva received her bachelor's and master's degrees in chemical technology of organic substances from Toraigyrov University (Pavlodar, Kazakhstan). Currently, she is a Ph.D. student at the Eurasian National University named after L.N. Gumilyov (Astana, Kazakhstan). The field of her scientific research is the study of physicochemical mechanisms of interaction of nanoparticles of mesoporous dioxide silica with antitumor drugs. At the invitation of Professor Hongbo Zhang, she undergoes an internship at the Faculty of Natural Science and Engineering, Åbo Academy University, where, under the guidance of Professor Sergey Filippov, she performs the experimental part of her work. |
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Emel Bakay. "My name is Emel Bakay. I am a new PhD student in PSL, Science and Engineering Depatment, Abo Akademi University, Turku, Finland. I completed my bachelor and master studies in Biomedical Engineering Department, Izmir Katip Celebi University, Turkey. My bachelor and master studies include the investigation of biomaterials and biomedical optic applications for therapeutic approaches. In my doctoral study, I will focus on design of specific tracers and nanoparticles on cancer metastasis for PET imaging. This process includes synthesis and characterizations of tracers and nanoparticles and their in-vivo applications under the supervision of Prof. Jessica Rosenholm from PSL, Abo Akademi University and Dr. Xiang-Guo Li from Turku PET Center. This study will be completed as collaboration with PSL at Abo Akademi University and Turku PET Center." |
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Nya publikationer | New publications |
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Året har börjat med många nya publikationer. En komplett lista av publikationer från PSL hittar ni här! The year has begun with many new publications! A complete list of PSL publications can be found here! |
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In this review we have analyzed the current clinical pipeline of antiviral drug development against herpes simplex virus infections. We have focused on how different approaches have been utilized for designing new therapies. Even if the topic is specific to herpes simplex viruses, we believe that the perspectives presented in this review are beneficial for researchers interested in drug development in general.
https://doi.org/10.1002/SMMD.20220004 |
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In this study, we discovered destabilizers of the dimeric human thymidylate synthase (hTS) as an alternative to the current clinical hTS inhibitors (such as fluorouracil). The current drugs lose their efficacy in the course of the treatment due to development of drug resistance that is associated with overexpression of hTS. We were able to show that the newly discovered compounds shift the dimerization equilibrium of both the recombinant and the intracellular hTS protein toward the inactive monomers. The best compound E7, inhibits hTS in cancer cells and accelerates its proteasomal degradation, thus causing a decrease in the enzyme intracellular level and providing a strategy to fight drug-resistant cancers.
https://doi.org/10.7554/eLife.73862 |
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The aim of the study was to demonstrate the social impact of the high-priced orphan drug nusinersen based on the views of involved experts within the Finnish community. The study was conducted using two methods for data collection: a media analysis and qualitative semi-structured interviews, and the overall data were analysed thematically. The results of the study show that the social impact of the drug appears somewhat different as seen from patient and decision-maker perspectives. For patients, the most relevant social impact is the drug becoming available to at least part of the patient group, the positive effects of the drug for patients receiving treatment and the establishment of a disease-specific patient organisation advocating for them. For decision-makers, on the other hand, joint price negotiations due to the establishment of a national HTA coordination unit, the healthcare reform addressing issues with respect to high-priced orphan drugs and the establishment of centres on rare diseases. https://doi.org/10.1016/j.rcsop.2023.100227 |
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We summarize the state-of-the-art advances in the delivery of oral antibiotics. In this review, the emergency of bacterial infection and the effect of excessive antibiotics are discussed at first. Then, current attempts to prevent microflorae from resistance and dysbiosis are briefly enumerated, including oral co-administration systems (like protectors, adsorbents, activity enhancers, etc.) and nanoparticle-based delivery systems. https://doi.org/10.1016/j.bmt.2022.11.010 |
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In this review, we summarize the design and development of micro-nano hydrogels for biomedical applications, first introduce biopolymers for the synthesis of hydrogels, then introduce the preparation technologies of microgels and nanogels respectively, and systematically summarize the application characteristics and forms of different preparation technologies. https://doi.org/10.1016/j.bmt.2022.11.012 |
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Platinum-based chemotherapy remains the main systemic treatment of ovarian cancer (OC). However, the inevitable development of platinum and poly (ADP-ribose polymerase (PARP) inhibitor (PARPi) resistance is associated with poor outcomes, which becomes a major obstacle in the management of this disease. The present study developed ‘all-in-one’ nanoparticles that contained the PARPi olaparib and gallium (Ga) (III) (olaparib-Ga) to effectively reverse PARPi resistance in platinum-resistant A2780-cis and SKOV3-cis OC cells and in SKOV3-cis tumor models. https://doi.org/10.34133/research.0070 |
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We report three patients diagnosed with rhabdomyolysis 1-6 months after the initiation of concomitant rosuvastatin and ticagrelor medication. In the literature and in the FDA adverse event reporting system, we found additional forty reports of rhabdomyolysis during concomitant ticagrelor and rosuvastatin. In this study, we carried out in vitro studies and drug-drug interaction predictions, which indicated that inhibition of the breast cancer resistance protein (BCRP) -mediated transport of rosuvastatin in the gut by ticagrelor is likely the cause of the observed interaction. https://doi.org/10.1111/bcp.15684 |
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This review focuses on the development of lung cancer surgery history, summarizing the era from traditional surgery to the era of minimally invasive thoracic surgery based on TV-assisted thoracic surgery. https://doi.org/10.1016/j.engreg.2022.12.001 |
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This review first discusses the early monotherapy and structural design of DNAzymes. Subsequently, the latest modes of action are reviewed, followed by an elaboration on structural stabilization strategies considering the catalytic core and substrate-binding arms. DNAzyme-based synergistic therapy is then examined, highlighting responsive carrier construction, synergistic effects, the latest discovered advanced functions, and off-target concerns. Beyond this, key clinical advances in DNAzyme-based therapy are elucidated by showcasing clinical progress. https://doi.org/10.1002/adma.202300374 |
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The in vivo experiments further prove that the synergistic antibacterial effect promotes wound disinfection and implant-related biofilm removal. This work highlights the engineering of efficient SAzymes for combating bacterial infections from superficial to deep tissues. https://doi.org/doi/10.34133/research.0031 |
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